ABSTRACT Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps.Recent reports have suggested a link between vesicular trafficking and antifungal resistance.Here, we identified novel Cryptococcus neoformans regulators of extracellular vesicle (EV) bioge
A growing number of inborn errors Table Accessory Set of metabolism (IEM) have been identified that manifest 3-methylglutaconic (3MGC) aciduria as a phenotypic feature.In primary 3MGC aciduria, IEM-dependent deficiencies in leucine pathway enzymes prevent catabolism of trans-3MGC CoA.Consequently, this metabolite is converted to 3MGC acid and excre
Abstract Pioneering flexible micro-supercapacitors, designed for exceptional energy and power density, transcend conventional storage limitations.Interdigitated electrodes (IDEs) based on laser-induced graphene (LIG), augmented with metal-oxide modifiers, harness synergies Wooden Frame LED Night Light with layered graphene to achieve superior capac
Amelia L Persico, 1, 2 Erica L Wegrzyn, 1, 2 Jeffrey Fudin, 1, 2 Michael E Schatman 3, 4 1Stratton VA Medical Center, Albany, NY, USA; 2Remitigate Therapeutics, Delmar, NY, USA; 3Tufts University School of Dental Medicine, Boston, MA, USA; 4Tufts University School of Medicine, Boston, MA, USACorrespondence: Jeffrey Fudin Email [email protected] The o